Age-associated B cell infiltration in salivary glands represents a hallmark of Sjogren's-like disease in aging mice.

ABSTRACT: Sjögren's disease (SjD), characterized by circulating autoantibodies and exocrine gland inflammation, is typically diagnosed in women over 50 years of age. However, the contribution of age to SjD pathogenesis is unclear. C57BL/6 female mice at different ages were studied to investigate how aging influences the dynamics of salivary gland inflammation. Salivary glands were characterized for immune cell infiltration, inflammatory gene expression, and saliva production. At 8 months, gene expression of several chemokines involved in immune cell trafficking was significantly elevated. At this age, age-associated B cells (ABCs), a unique subset of B cells expressing the myeloid markers CD11b and/or CD11c, were preferentially enriched in the salivary glands compared to other organs like the spleen

SUBMITTER: Bagavant H 

PROVIDER: S-EPMC11493885 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature