Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review.

ABSTRACT: Cardiorespiratory fitness (CRF) not only reflects an individual's capacity to perform physical activities but also encapsulates broader effects on the basic biology of aging. This review aims to summarize the evidence on the influence of CRF on overall and site-specific cancer risks. It delves into the biological mechanisms through which CRF may exert its effects, explores the clinical implications of these findings, identifies gaps in the current evidence base, and suggests directions for future research. The synthesis of findings reveals that higher CRF levels (general threshold of > 7 METs) are consistently associated with a reduced risk of a range of cancers, including head and neck, lung, breast, gastrointestinal, particularly pancreatic and colorectal, bladder, overall cancer inciden

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC11493895 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature