Modulation of neural gene networks by estradiol in old rhesus macaque females.

ABSTRACT: The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene expression and DNA methylation (DNAm) patterns in the nonhuman primate brain following ovariectomy (Ov) and subsequent subcutaneous bioidentical E2 chronic treatment. We identified several dysregulated molecular networks, including MAPK signaling and dopaminergic synapse response, that are associated with ovariectomy and shared across two different brain areas, the occipital cortex (OC) and prefrontal cortex (PFC). The finding that hypomethylation (p = 1.6 × 10^-51) and upregulation (p = 3.8 × 10^-3) of UBE2M across both brain regions pr

SUBMITTER: Cervera-Juanes R 

PROVIDER: S-EPMC11493911 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature