Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study.

ABSTRACT: Considerable uncertainty remains regarding the associations of multiple factors with brain health. We aimed to conduct an exposome-wide association study on neurodegenerative disease and neuropsychiatry disorders using data of participants from the UK Biobank. Multivariable Cox regression models with the least absolute shrinkage and selection operator technique as well as principal component analyses were used to evaluate the exposures in relation to common disorders of central nervous system (CNS). Restricted cubic splines were conducted to explore potential nonlinear correlations. Then, weighted standardized scores were generated based on the coefficients to calculate the joint effects of risk factors. We also estimated the potential impact of eliminating the unfavorable profiles of risk

SUBMITTER: Huang LY 

PROVIDER: S-EPMC11493923 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature