LINC01518 predicts poor prognosis of prostate cancer and promotes its progression by regulating hsa-miR-320a/CNKSR2 axis.

ABSTRACT:

Background

Prostate cancer (PCa) is the most common malignancy of the male genitourinary system. Understanding the molecular mechanism of PCa and its prognostic markers will assist in the selection of better treatment.

Aim

To explore the role of LINC01518 in the development of PCa and its prognostic value, and to understand its specific regulatory mechanism.

Methods

The levels of LINC01518, hsa-miR-320a, and CNKSR2 mRNA were detected by RT-qPCR. ROC curve was constructed to evaluate the prognostic value of LINC01518 in PCa. The effects of LINC01518 on the functions of PCa cells were demonstrated by CCK-8, Transwell test, and the detection of apoptotic markers, after LINC01518 knockdown. The interaction between hsa-miR-320a and LINC01518 or CNKSR2 mRNA was examined by

SUBMITTER: Chen G 

PROVIDER: S-EPMC11493929 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature