Everolimus alleviates CD4⁺ T cell inflammation by regulating autophagy and cellular redox homeostasis.

ABSTRACT: Aging is associated with the onset and progression of multiple diseases, which limit health span. Chronic low-grade inflammation in the absence of overt infection is considered the simmering source that triggers age-associated diseases. Failure of many cellular processes during aging is mechanistically linked to inflammation; however, the overall decline in the cellular homeostasis mechanism of autophagy has emerged as one of the top and significant inducers of inflammation during aging, frequently known as inflammaging. Thus, physiological or pharmacological interventions aimed at improving autophagy are considered geroprotective. Rapamycin analogs (rapalogs) are known for their ability to inhibit mTOR and thus regulate autophagy. This study assessed the efficacy of everolimus, a rapalog,

SUBMITTER: Rockhold JD 

PROVIDER: S-EPMC11493941 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature