High-resolution transcranial optical imaging of in vivo neural activity.

ABSTRACT: Rapid sub-nanometer neuronal deformations have been shown to occur as a consequence of action potentials in vitro, allowing for optical registration of discrete axonal and synaptic depolarizations. Such optically-measured deformations are a novel signature for recording neural activity. We demonstrate this signature can be extended to in vivo measurements through recording of rapid neuronal deformations on the population level with holographic, optical phase-based recordings. Our system demonstrates, for the first time, non-invasive recordings of in vivo tissue deformation associated with population level neuronal activity, including through-skull. We confirmed this technique across a range of neural activation models, including direct epidural focal electrical stimulation, anesthetic-indu

SUBMITTER: Lefebvre AT 

PROVIDER: S-EPMC11493950 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature