Mitochondrial-derived peptides, HNG and SHLP3, protect cochlear hair cells against gentamicin.

ABSTRACT: Preservation of hair cells is critical for maintaining hearing function, as damage to sensory cells potentially leads to irreparable sensorineural hearing loss. Hair cell loss is often associated with inflammation and oxidative stress. One promising class of bioactive peptides is mitochondrial-derived peptides (MDPs), which have already been proven to protect various tissues from cellular stresses and delay aging processes. Humanin (HN) is one of the best-known members of this family, and recently, we have shown its protective effect in hair cells. The synthetic derivate HN S14G (HNG) has a more potent protective effect than natural HN making it a more useful peptide candidate to promote cytoprotection. A less-known MDP is small humanin-like peptide 3 (SHLP3), which has cytoprotective effe

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11493991 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature