Losartan and enalapril maleate differently influence SARS-CoV-2-infected vero cells.

ABSTRACT:

Background

The COVID-19 pandemic has posed significant challenges to global healthcare systems, particularly impacting individuals with pre-existing conditions like hypertension. This study sought to assess the impact of the antihypertensive medications, losartan and enalapril maleate on SARS-CoV-2 infected cells. Vero E6 cells were infected and treated in vitro, evaluating cell viability via the MTT colorimetric assay. Additionally, the study measured relative levels of viral RNA and selected gene messenger RNAs using reverse transcriptase followed by quantitative real-time polymerase chain reaction.

Results

The findings revealed that losartan substantially reduced nucleocapsid RNA levels of SARS-CoV-2 to nearly undetectable levels, while enalapril maleate did not demonstra

SUBMITTER: Majolo JH 

PROVIDER: S-EPMC11493994 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature