Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit.

ABSTRACT: Bilateral alternation of muscle contractions requires reciprocal inhibition between the two sides of the hindbrain and spinal cord, and disruption of this inhibition should lead to simultaneous activation of bilateral muscles. At 1 day after fertilization, wild-type zebrafish respond to mechanosensory stimulation with multiple fast alternating trunk contractions, whereas bandoneon (beo) mutants contract trunk muscles on both sides simultaneously. Similar simultaneous contractions are observed in wild-type embryos treated with strychnine, a blocker of the inhibitory glycine receptor (GlyR). This result suggests that glycinergic synaptic transmission is defective in beo mutants. Muscle voltage recordings confirmed that muscles on both sides of the trunk in beo are likely to receive simultane

SUBMITTER: Hirata H 

PROVIDER: S-EPMC1149420 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature