Clinical Outcomes Associated with Amoxicillin Treatment for Acute Otitis Media in Children.

ABSTRACT:

Background

Acute otitis media (AOM) is the most common reason children are prescribed antibiotics. Bacteria that produce beta-lactamase are an increasingly frequent cause of AOM and may be resistant to amoxicillin, the currently recommended treatment for AOM. We aimed to evaluate the clinical outcomes of children treated with amoxicillin for AOM and assessed whether outcomes vary by infecting pathogen or beta-lactamase production.

Methods

205 children 6-35 months old diagnosed with AOM and prescribed amoxicillin were included. Bacterial culture and qualitative multiplex real-time polymerase chain reaction were performed on nasopharyngeal swabs collected at enrollment. Parents completed surveys assessing symptoms, antibiotic adherence, and potential adverse events. The primar

SUBMITTER: Frost HM 

PROVIDER: S-EPMC11494229 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature