Prior <i>Trichinella spiralis</i> infection protects against <i>Schistosoma mansoni</i> induced hepatic fibrosis.

ABSTRACT:

Background

Schistosomiasis affects approximately 250 million people worldwide, with 200,000 deaths annually. It has been documented that the granulomatous response to Schistosoma mansoni (S. mansoni) oviposition is the root cause of progressive liver fibrosis in chronic infection, in 20% of the patients, and can lead to liver cirrhosis and/or liver cancer. The influence of helminths coinfection on schistosomiasis-induced liver pathological alterations remains poorly understood. Therefore, in this study, we investigated the effect of Trichinella spiralis (T. spiralis) infection on S. mansoni-induced hepatic fibrosis.

Materials and methods

Thirty adult male Balb-c mice were divided into three groups. Group 1 was left uninfected; group 2 was i

SUBMITTER: El-Kady AM 

PROVIDER: S-EPMC11494294 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature