Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis.

ABSTRACT: Cardiac myosin-specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis). To determine whether MyHC T cells are tissue-resident memory T (T_RM) cells, we characterized cardiac T_RM cells in naive mice and established that they have a distinct phenotypic and transcriptional profile that can be defined by their upregulation of CD69, PD-1, and CXCR6. We then investigated the effects of cardiac injury through a modified experimental autoimmune myocarditis mouse model and an ischemia-reperfusion injury mouse model and determined that cardiac inflammation induces the recruitment of autoreactive MyHC T_RM cells, which coexpress PD-1 and CD69. To investigate whether the recruited MyHC T_RM

SUBMITTER: Kalinoski H 

PROVIDER: S-EPMC11494310 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature