Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection.

ABSTRACT: Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.

SUBMITTER: Kessler S 

PROVIDER: S-EPMC11494324 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature