Association between air pollution and bone mineral density: a Mendelian randomization study.

ABSTRACT:

Introduction

The association of air pollution with bone mineral density (BMD) has attracted increasing attention. However, establishing a causal relationship remains uncertain.

Methods

We conducted a Mendelian randomization (MR) study employing PM_2.5, PM_2.5-10, PM₁₀, nitrogen dioxide, and nitrogen oxides as exposures and BMD as the outcome to explore the causality between air pollution and the occurrence of decreased BMD.

Results

By employing the IVW method, we identified a negative causality between air pollution (PM_2.5, PM₁₀, and nitrogen oxides) and BMD.

Conclusions

Our findings demonstrate that PM_2.5, PM₁₀ and nitrogen oxides exposure may contribute to decreased BMD.

SUBMITTER: Jiang R 

PROVIDER: S-EPMC11494361 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature