Altered pain processing and sensitization in sickle cell disease: a scoping review of quantitative sensory testing findings.

ABSTRACT:

Objectives

Over 50% of adults living with sickle cell disease (SCD) have chronic pain, but the underlying mechanisms of chronic pain in this population remain unclear. Quantitative sensory testing is an important measurement tool for understanding pain and sensory processing. This scoping review summarizes quantitative sensory testing methodologies used in sickle cell studies and the evidence for central sensitization in this population.

Methods

We conducted a systematic search of PubMed, Embase, and CINAHL to identify studies using quantitative sensory testing in individuals living with sickle cell disease. Search strategies were based on variations of the terms "sickle cell disease," and "quantitative sensory testing." Eligible studies were observational or experimental st

SUBMITTER: Kenney MO 

PROVIDER: S-EPMC11494381 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature