Three-component modular synthesis of chiral 1,3-dioxoles <i>via</i> a Rh-catalyzed carbenic olefination cascade.

ABSTRACT: The advance of organic synthesis and the discovery of novel chemical transformations are often propelled by the rational programming of various bond-forming mechanisms and sequences that involve delicate reactive intermediates. In this study, we present an innovative Rh(ii)-catalyzed asymmetric three-component cascade reaction involving I^III/P^V-hybrid ylides, aldehydes, and carboxylic acids for the synthesis of 1,3-dioxoles with moderate to good yields and high enantioselectivity. This method utilizes I^III/P^V-hybrid ylides as carbene precursors to form α-P^V-Rh-carbenes, which initiate the formation of carbonyl ylides, followed by stereoselective cyclization with carboxylate anions and an intramolecular Wittig olefination cascade, ultim

SUBMITTER: Huang S 

PROVIDER: S-EPMC11494413 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature