Photoinduced copper-catalyzed asymmetric cyanoalkylalkynylation of alkenes, terminal alkynes, and oximes.

ABSTRACT: The asymmetric dicarbofunctionalization of alkenes via a radical relay process can provide routes to diverse hydrocarbon derivatives. Three-component carboalkynylation, limited to particular alkyl halides and using readily available cycloketone oxime esters as redox-active precursors, is restricted by the available pool of suitable chiral ligands for broadening the redox potential window of copper complexes and simultaneously creating the enantiocontrol environment. Herein, we report a new hybrid tridentate ligand bearing a guanidine-amide-pyridine unit for photoinduced copper-catalyzed cyanoalkylalkynylation of alkenes. Leveraging the copper catalyst's redox capability is achieved via merging the electron-rich ligand with a readily organized configuration and enhanced absorp

SUBMITTER: Xin S 

PROVIDER: S-EPMC11494415 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature