Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology.

ABSTRACT:

Objective

We intended to investigate the relationships between visual sensory impairment (VSI) or auditory sensory impairment (ASI) and brain pathological changes associated with cognitive decline in older adults.

Methods

We primarily tried to examine whether each sensory impairment is related to Alzheimer's disease (AD) pathology, specifically beta-amyloid (Aβ) deposition, through both cross-sectional and longitudinal approaches in cognitively unimpaired older adults. Self-report questionnaires on vision and hearing status were administered at the baseline. Neuroimaging scans including brain [¹¹C] Pittsburgh Compound B PET and MRI, as well as clinical assessments, were performed at baseline and 2-year follow-up.

Results

Cross-sectional analyses showed that

SUBMITTER: Byeon G 

PROVIDER: S-EPMC11494423 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature