Cardiovascular responses to heat and cold exposure are altered by preterm birth in guinea pigs.

ABSTRACT: Adversity early in life can modify the trajectory for disease risk extending decades beyond the event. Preterm birth produces persistent cardiovascular alterations that may appear maladaptive in adulthood. We have previously hypothesized that those born preterm may exhibit cardiovascular vulnerability in the climate change context. Further, this vulnerability may be present as early as childhood. We aimed to identify the early signs of cardiovascular dysfunction at childhood-equivalent age using our animal model of preterm birth. Using a whole-body thermal stress test, guinea pigs aged 35-d and 38-d (equivalent to 8-10-year-old children) and born at term or preterm gestations were exposed to progressive hyper- (T_C = 41.5°C) and hypo-thermia (T_C = 34°C; normothermia T<

SUBMITTER: Sixtus RP 

PROVIDER: S-EPMC11494451 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature