Free-energy transduction mechanisms shape the flux space of metabolic networks.

ABSTRACT: The transduction of free energy in metabolic networks represents a thermodynamic mechanism by which the free energy derived from nutrients is converted to drive nonspontaneous, energy-requiring metabolic reactions. This transduction is typically observed in processes that generate energy-rich molecules such as ATP and NAD(P)H, which, in turn, power specific reactions, particularly biosynthetic reactions. This property establishes a pivotal connection between the intricate topology of metabolic networks and their ability to redirect energy for functional purposes. The present study proposes a dedicated framework aimed at exploring the relationship between free-energy dissipation, network topology, and metabolic objectives. The starting point is that, regardless of the network topology, none

SUBMITTER: Pfeuty B 

PROVIDER: S-EPMC11494513 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature