Impact of tumor location and pleural invasion on the frequency of skip hilar lymph node metastasis in lung cancer.

ABSTRACT:

Background

The appropriate extent of hilar lymph node (LN) dissection in segmentectomy for lung cancer has not yet been fully investigated. Herein, we assessed the patterns of LN metastasis using network analyses.

Methods

Patients with nodal metastases of non-small-cell lung cancer measuring ≤30 mm in diameter who underwent anatomical resection were included. The assumed pathways of metastasis were visualized using Cytoscape software. Metastasis to hilar (#10) or interlobar (#11) LNs but not to more peripheral ones was defined as skip N1 metastasis.

Results

A total of 322 patients were included, with 123 of them having pleural invasive tumors and 32 having intrapulmonary metastases. There were 130 patients with pN1 disease and 192 with pN2 disease. The overall proport

SUBMITTER: Ichinose J 

PROVIDER: S-EPMC11494562 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature