Peripheral immunological characteristics of spontaneous pneumothorax: a Mendelian randomization study.

ABSTRACT:

Background

Spontaneous pneumothorax (SP) is a common pleural disease in adolescents and adults. However, the role of immunological characteristics in the pathogenesis of SP remains unclear. This study aims to clarify the causal associations between circulating immune cells, lymphocyte subgroups, and SP susceptibility.

Methods

Employing Mendelian randomization (MR), the causal association between circulating immune blood cells and lymphocyte subgroups on SP susceptibility have been assessed. Reverse MR analysis was used to further explore the causal relationship. The MR analysis ensured the reliability of the study results through the deletion of confounding single nucleotide polymorphisms (SNPs), heterogeneity testing, sensitivity analysis.

Results

Seven immune cells

SUBMITTER: Ruan L 

PROVIDER: S-EPMC11494576 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature