Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study.

ABSTRACT: Biological age is a construct that seeks to evaluate the biological wear and tear process of the organism that cannot be observed by chronological age. We estimate individuals' biological age based on biomarkers from multiple systems and validate it through its association with mortality from natural causes. Biological age was estimated in 12,109 participants (6621 women and 5488 men) from the first visit of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had valid data for the biomarkers used in the analyses. Biological age was estimated using the Klemera and Doubal method. The difference between chronological age and biological age (Δage) was computed. Cox proportional hazard models stratified by sex were used to assess whether Δage was associated with mortality risk a

SUBMITTER: Machado AV 

PROVIDER: S-EPMC11494676 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature