Development and validation of a chronic kidney disease progression model using patient-level simulations.

ABSTRACT: Chronic disease progression models are available for several highly prevalent conditions. For chronic kidney disease (CKD), the scope of existing progression models is limited to the risk of kidney failure and major cardiovascular (CV) events. The aim of this project was to develop a comprehensive CKD progression model (CKD-PM) that simulates the risk of CKD progression and a broad range of complications in patients with CKD. A series of literature reviews informed the selection of risk factors and identified existing risk equations/algorithms for kidney replacement therapy (KRT), CV events, other CKD-related complications, and mortality. Risk equations and transition probabilities were primarily sourced from publications produced by large US and international CKD registries. A patient-lev

SUBMITTER: Ramos M 

PROVIDER: S-EPMC11494709 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature