Carotid intima-media thickness, fibroblast growth factor 23, and mineral bone disorder in children with chronic kidney disease.

ABSTRACT:

Background

Carotid intima-media thickness (cIMT) is a measure of atherosclerotic vascular disease and a surrogate biomarker for cardiovascular risk in patients with chronic kidney disease (CKD). Mineral and bone disorders (MBD) are complications of CKD, contributing to vascular calcification and accelerated atherosclerosis. Increased fibroblast growth factor 23 (FGF23)-the earliest detectable serum abnormality associated with CKD-MBD-has been linked with cardiovascular disease in patients with CKD. This study aimed to identify factors and analyze the relationship associated with high cIMT, high FGF23, and poor MBD control in children with CKD.

Methods

A cross-sectional study was conducted in Yogyakarta, Indonesia recruiting children with CKD. The correlations and factors bet

SUBMITTER: Palupi-Baroto R 

PROVIDER: S-EPMC11494757 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature