Association between loneliness and incident atrial fibrillation across different genetic predisposition: findings from the UK Biobank.

ABSTRACT:

Background

Loneliness has garnered significant attention globally, with extensive exploration of its association with cardiovascular disease. However, a notable research gap persists concerning loneliness and its potential link to atrial fibrillation (AF).

Methods

This prospective cohort study utilized data from the UK Biobank (UKB), encompassing 441,056 participants. Loneliness was assessed through self-reported questionnaires gauging feelings of isolation and willingness to confide. AF diagnoses were ascertained using hospitalization records and cause-of-death registry data. The association between loneliness and AF risk was analyzed through multivariable Cox proportional hazard models.

Results

Over a median follow-up period of 13.9 years, 25,386 AF cases were ident

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11494771 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature