Oncolytic avian reovirus-sensitized tumor infiltrating CD8⁺ T cells triggering immunogenic apoptosis in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is a leading malignant disease in numerous countries, including Taiwan with limited therapeutic options. Animal viruses including oncolytic avian reovirus (ARV) have the possibility to avoid pre-existing immunity in humans, while being safe and immunostimulatory. Here, we provide a novel insight into oncolytic ARV and UV-ARV-sensitized patient's peripheral blood mononuclear cells (P-PBMCs) and tumor infiltrating lymphocytes (TILs) killing primary GC (PGC) cells through the surface TLR3 and TRAIL/DR4/DR5 immunogenic apoptosis pathway.

Methods

We conducted a comprehensive study to reveal whether ARV- or UV-inactivated ARV (UV-ARV)-modulated P-PBMCs or TILs killing ARV- and UV-ARV-sensitized AGS cells and PGC cells derived from clinical patients a

SUBMITTER: Wu YY 

PROVIDER: S-EPMC11494775 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature