Bovine pulp extracellular matrix hydrogel for regenerative endodontic applications: in vitro characterization and in vivo analysis in a necrotic tooth model.

ABSTRACT:

Background

Regenerative endodontic procedures (REPs) offer the promise of restoring vitality and function to a previously necrotic and infected tooth. However, the nature of regenerated tissues following REPs remains unpredictable and uncontrollable. Decellularized extracellular matrix scaffolds have gained recent attention as scaffolds for regenerative endodontics.

Objectives

Preparation and characterization of a bovine dental pulp-derived extracellular matrix (P-ECM) hydrogel for regenerative endodontic applications. Biocompatibility and regenerative capacity of the prepared scaffold were evaluated in vivo in a canine animal model.

Methods

Fifteen freshly extracted bovine molar teeth were used to prepare P-ECM hydrogels following approval of the institutional review

SUBMITTER: Elnawam H 

PROVIDER: S-EPMC11494807 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature