Genomic insight on Klebsiella variicola isolated from wastewater treatment plant has uncovered a novel bacteriophage.

ABSTRACT: Klebsiella variicola is considered an emerging pathogen, which may colonize a variety of hosts, including environmental sources. Klebsiella variicola investigated in this study was obtained from an influent wastewater treatment plant in the North-West Province, South Africa. Whole genome sequencing was conducted to unravel the genetic diversity and antibiotic resistance patterns of K. variicola. Whole genome core SNP phylogeny was employed on publicly available 170 genomes. Furthermore, capsule types and antibiotic resistance genes, particularly beta-lactamase and carbapenems genes were investigated from the compared genomes. A 38 099 bp bacteriophage was uncovered alongside with K. variicola genome. Whole genome sequencing revealed that the extended beta-lactamase bla_LEN (75.3%

SUBMITTER: Lekota KE 

PROVIDER: S-EPMC11494819 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature