eIF6 deficiency regulates gut microbiota, decreases systemic inflammation, and alleviates atherosclerosis.

ABSTRACT: Altered composition of the gut microbiota affects immunity and metabolism. This study previously found that eIF6 gene knockdown changes the composition of the intestinal flora in the eIF6 gene knockdown mouse model. Lactobacillus acidophilus is significantly increased in the model. This study was designed to investigate the role of L. acidophilus in the pathogenesis of atherosclerosis. Transcriptomic data from 117 patients with coronary artery disease (CAD) and 79 healthy individuals were obtained. ApoE^-/- and ApoE^-/-/eIF6^+/- mice on normal chow diet or a high-fat diet were treated for 16 weeks; eIF6 deficiency was evaluated atherosclerosis. ApoE^-/- mice on normal chow diet or a high-

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11494895 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature