Distinct negative-sense RNA viruses induce a common set of transcripts encoding proteins forming an extensive network.

ABSTRACT: The large group of negative-strand RNA viruses (NSVs) comprises many important pathogens. To identify conserved patterns in host responses, we systematically compared changes in the cellular RNA levels after infection of human hepatoma cells with nine different NSVs of different virulence degrees. RNA sequencing experiments indicated that the amount of viral RNA in host cells correlates with the number of differentially expressed host cell transcripts. Time-resolved differential gene expression analysis revealed a common set of 178 RNAs that are regulated by all NSVs analyzed. A newly developed open access web application allows downloads and visualizations of all gene expression comparisons for individual viruses over time or between several viruses. Most of the genes included in the core

SUBMITTER: Hofmann N 

PROVIDER: S-EPMC11494938 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature