Oral co-administration of <i>Lactiplantibacillus plantarum</i> 16 and <i>Lacticaseibacillus rhamnosus</i> P118 improves host defense against influenza A virus infection.

ABSTRACT: Influenza is an important zoonotic disease that persistently threatens global public health. While it is widely acknowledged that probiotics can modulate the host response to protect the host against infectious disease, the prophylactic efficacy on respiratory viral infection and the detailed mechanism remains elusive. Lactobacillus, the most commonly used probiotic widely applied in food production, has garnered significant attention. In our study utilizing both C57BL/6 and BALB/c mouse models, we explored the protective effect against two strains of influenza virus, A/Mink/China/01/2014(H9N2) and A/California/04/2009(H1N1), through the administration of Lactiplantibacillus plantarum strain 16 (L. plantarum 16) and Lacticaseibacillus rhamnosus strain P118 (L

SUBMITTER: Han M 

PROVIDER: S-EPMC11494971 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature