HIV-induced RSAD2/Viperin supports sustained infection of monocyte-derived macrophages.

ABSTRACT: HIV establishes long-term latent infection in memory CD4⁺ T cells and also establishes sustained long-term productive infection in macrophages, especially in the central nervous system (CNS). To better understand how HIV sustains infection in macrophages, we performed RNAseq analysis after infection of human monocyte-derived macrophages (MDMs) with the brain-derived HIV-1 strain YU2 and compared this with acute infection of CD4⁺ T cells. HIV infection in MDM and CD4⁺ T cells altered many gene transcripts, but with few overlaps between these different cell types. We found interferon pathways upregulated in both MDM and CD4⁺ T cells, but with different gene signatures. The interferon-stimulated gene RSAD2/Viperin was among the most upregulated gene

SUBMITTER: Zankharia U 

PROVIDER: S-EPMC11494996 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature