Evolution of ceftazidime-avibactam resistance driven by mutations in double-copy bla_KPC-2 to bla_KPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae.

ABSTRACT: Klebsiella pneumoniae carbapenemase (KPC) variants can contribute to resistance to ceftazidime-avibactam (CZA) in Klebsiella pneumoniae (KP). However, two-copy KPC variant-mediated resistance to CZA has rarely been reported to date. Here, we aimed to clarify the evolutionary trajectory of CZA resistance driven by mutations in double-copy bla_KPC-2 to bla_KPC-189 carried by the tandem core structure (ISKpn6-bla_KPC-ISKpn27-tnpR-IS26) during treatment of ST11 carbapenem-resistant K. pneumoniae (CRKP). The CZA-resistant KP strain carried double-copy bla_KPC-189, a variant with alanine-threonine and aspartate-tyrosine substitutions at Ambler amino acid positions 172 (A172T) and 179 (D179Y) of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11495026 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature