A "plus one" strategy impacts replication of felid alphaherpesvirus 1, <i>Mycoplasma</i> and <i>Chlamydia,</i> and the metabolism of coinfected feline cells.

ABSTRACT: Coinfections are known to play an important role in disease progression and severity. Coinfections are common in cats, but no coinfection studies have investigated the in vitro dynamics between feline viral and bacterial pathogens. In this study, we performed co-culture and invasion assays to investigate the ability of common feline bacterial respiratory pathogens, Chlamydia felis and Mycoplasma felis, to replicate in and invade into Crandell-Rees feline kidney cells. We subsequently investigated how coinfection of these feline cells with each bacterium (C. felis or M. felis) and the common feline viral pathogen, felid alphaherpesvirus 1 (FHV-1), affects replication of each agent in this cell culture system. We also investigated the metabolic impact of ea

SUBMITTER: Klose SM 

PROVIDER: S-EPMC11495031 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature