A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson's disease.

ABSTRACT: Seeding activities of disease-associated α-synuclein aggregates (αSyn^D), a hallmark of Parkinson's disease (PD), are detectable by seed amplification assay (αSyn-SAA) and being developed as a diagnostic biomarker for PD. Sensitive and accurate αSyn-SAA for blood or saliva would greatly facilitate PD diagnosis. This prospective diagnostic study conducted αSyn-SAA analyses on serum and saliva samples collected from patients clinically diagnosed with PD or healthy controls (HC). 124 subjects (82 PD, 42 HC) donated blood and had extensive clinical assessments, of whom 74 subjects (48 PD, 26 HC) also donated saliva at the same visits. An additional 57 subjects (35 PD, 22 HC) donated saliva and had more limited clinical assessments. The mean ages were 69.21, 66.55, 69.58, and 64.71 ye

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11495072 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature