Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury.

ABSTRACT:

Background

Delirium affects 50-85% of patients on mechanical ventilation and is associated with increased mortality, prolonged hospitalization, and a three-fold higher risk of dementia. Microglia, the resident immune cells of the brain, exhibit both neuroprotective and neurotoxic functions; however, their effects in mechanical ventilation-induced acute lung injury (VILI) are unknown. We hypothesize that in a model of short-term VILI, microglia play a neuroprotective role to ameliorate delirium-like phenotypes.

Methods

Microglia depletion (n = 18) was accomplished using an orally administered colony stimulating factor 1 receptor inhibitor, while controls received a vehicle diet (n = 18). We then compared extent of neuronal injury in the frontal cortex and hippocampus using cl

SUBMITTER: Scott L 

PROVIDER: S-EPMC11495074 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature