Prolonged exposure to air pollution and risk of acute kidney injury and related mortality: a prospective cohort study based on hospitalized AKI cases and general population controls from the UK Biobank.

ABSTRACT:

Background

Previous investigations identified a connection between air pollution and kidney diseases. Nevertheless, there is a lack of comprehensive evidence on the long-term risks posed by air pollution with respect to acute kidney injury (AKI) and AKI-related death.

Methods

This prospective cohort analysis included 414,885 UK Biobank (UKB) participants who did not exhibit AKI at the study's outset. AKI was defined based on ICD-10 codes recorded for hospitalized patients. Cox proportional hazards models were used to assess the association between prolonged exposure to air pollutants (particulate matter with diameters of 2.5 micrometers or less (PM_2.5), between 2.5 and 10 micrometers (PM_2.5-10), and 10 micrometers or less (PM₁₀), along with n

SUBMITTER: Liu M 

PROVIDER: S-EPMC11495112 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature