An elegant approach for the synthesis of multisubstituted imidazole <i>via</i> FeCl₃/SiO₂ catalyzed activation of acetals: a photophysical study of an imidazole-carbazole hybrid.

ABSTRACT: A simple and solvent-free catalytic system was developed for the direct conversion of multisubstituted imidazoles through the reaction of acetals and benzils with ammonium acetate/amines as the source of nitrogen. The reaction occurred under mild and benign conditions using FeCl₃/SiO₂ as a heterogeneous catalyst without the requirement of any toxic organic solvents. The easy preparation and recyclability of the catalyst allows the reaction to be simple and highly efficient, resulting in very good yields of imidazoles. Novel imidazole-carbazole hybrid compounds were also synthesised by adopting the present methodology. Single crystal X-ray diffraction study indicated the presence of a CH⋯π supramolecular interaction that renders effective molecular packing in the solid

SUBMITTER: Das B 

PROVIDER: S-EPMC11495403 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature