Does Time to Asystole in Donors After Circulatory Death Impact Recipient Outcome in Liver Transplantation?

ABSTRACT:

Background

The agonal phase can vary following treatment withdrawal in donor after circulatory death (DCD). There is little evidence to support when procurement teams should stand down in relation to donor time to death (TTD). We assessed what impact TTD had on outcomes following DCD liver transplantation.

Methods

Data were extracted from the UK Transplant Registry on DCD liver transplant recipients from 2006 to 2021. TTD was the time from withdrawal of life-sustaining treatment to asystole, and functional warm ischemia time was the time from donor systolic blood pressure and/or oxygen saturation falling below 50 mm Hg and 70%, respectively, to aortic perfusion. The primary endpoint was 1-y graft survival. Potential predictors were fitted into Cox proportional hazards models

SUBMITTER: Malik AK 

PROVIDER: S-EPMC11495538 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature