Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.

ABSTRACT:

Background

Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, this study evaluated the effects of auranofin on H. capsulatum growth and expression of virulence factors.

Methodology/principal findings

Minimal inhibitory and fungicidal concentrations (MIC and MFC, respectively) of auranofin against 15 H. capsulatum strains with distinct genetic backgrounds were determined using the yeast form of the fungus and a microdilution protocol. Auranofin activity was al

SUBMITTER: de Abreu Almeida M 

PROVIDER: S-EPMC11495550 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature