Effects of insulin resistance and β-cell function on diabetic complications in Korean diabetic patients.

ABSTRACT:

Background

Diabetes mellitus is characterized by insulin resistance (IR) and dysfunctional insulin secretion from pancreatic β-cells. However, little research has been conducted on the relationship between IR and β-cell function in relation to diabetic complications among Korean diabetic patients. This study aimed to examine the differential associations between IR and β-cell function and various diabetic complications among Korean diabetic patients.

Methods

The analysis employed a common data model (CDM). IR and β-cell function were quantified using the homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. Hazard ratios for diabetic nephropathy, diabetic retinopathy, and cardiovascular disease (CVD) events were calculated.

SUBMITTER: Song DK 

PROVIDER: S-EPMC11495573 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature