Ethical acceptability of human challenge trials: Consultation with the US public and with research personnel.

ABSTRACT: Human challenge trials (HCTs) may accelerate the development of treatments and vaccines, and deliver novel insights into the course and consequences of infection. However, HCTs are contentious because they involve purposely exposing volunteers to infection. Consultation with the public and other stakeholders is essential for understanding how HCTs can be most ethically and acceptably pursued. Previous research has found public support for COVID-19 HCTs, but little research has considered public attitudes towards HCTs in principle and the various factors making a trial more or less acceptable. Empirical data on the attitudes of research personnel is also missing. We generated an online survey covering overarching support/opposition towards HCTs, as well as factors of importance for deciding

SUBMITTER: Elsey JWB 

PROVIDER: S-EPMC11495607 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature