Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure.

ABSTRACT: In patients with dyssynchronous heart failure (DHF), cardiac conduction abnormalities cause the regional distribution of myocardial work to be non-homogeneous. Cardiac resynchronization therapy (CRT) using an implantable, programmed biventricular pacemaker/defibrillator, can improve the synchrony of contraction between the right and left ventricles in DHF, resulting in reduced morbidity and mortality and increased quality of life. Since regional work depends on wall stress, which cannot be measured in patients, we used computational methods to investigate regional work distributions and their changes after CRT. We used three-dimensional multi-scale patient-specific computational models parameterized by anatomic, functional, hemodynamic, and electrophysiological measurements in eight patien

SUBMITTER: Craine A 

PROVIDER: S-EPMC11495643 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature