Procalcitonin-Guided Management and Duration of Antibiotic Therapy in Critically Ill Cancer Patients With Sepsis (Pro-Can Study): A Randomized Controlled Trial.

ABSTRACT:

Objectives

To evaluate the effect of procalcitonin-guided management on the duration of antibiotic therapy in critically ill cancer patients with sepsis.

Design

Randomized, controlled, single-blinded trial.

Setting

A comprehensive multidisciplinary cancer hospital in Jordan.

Patients

Adults with cancer treated in the ICU who were started on antibiotics for suspected infection, met the SEPSIS-3 criteria, and were expected to stay in the ICU greater than or equal to 48 hours.

Interventions

Patients were randomized to the procalcitonin-guided or standard care (SC) arms. All patients had procalcitonin measured daily, up to 5 days or until ICU discharge or death. For the procalcitonin arm, a procalcitonin-guided algorithm was provided to guide antibiotic mana

SUBMITTER: Nazer LH 

PROVIDER: S-EPMC11495690 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature