Causal association between hypothyroidism and obstructive sleep apnea: A bidirectional 2-sample Mendelian Randomization study.

ABSTRACT: Although previous epidemiological studies have investigated the correlation between hypothyroidism and obstructive sleep apnea (OSA), the results are controversial and conflicting. Therefore, we used a bidirectional 2-sample Mendelian randomization (MR) approach to infer the causal relationship between hypothyroidism and OSA. We performed a bidirectional 2-sample MR analysis to infer the causal relationship between hypothyroidism and OSA using genome-wide association study (GWAS) data. The hypothyroidism dataset was obtained from GWAS of the IEU database (https://gwas.mrcieu.ac.uk/). The GWAS dataset associated with OSA was obtained from the FinnGen Biobank (https://www.finngen.fi/en). MR results were estimated using the inverse variance weighted, weighted median, MR-Egger, simple mode, an

SUBMITTER: Lu N 

PROVIDER: S-EPMC11495703 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature