Investigating the genetic causal relationship between breast cancer and endometrial cancer: A two-sample Mendelian randomization study.

ABSTRACT: Observational studies have consistently shown a correlation between breast cancer (BC) and endometrial cancer (EC). Despite these findings, the causal relationship between these cancers has not been clearly defined. This research employed a bidirectional two-sample Mendelian randomization to explore the genetic causality between BC and EC. Genetic instruments for BC were derived from the Breast Cancer Association Consortium genome-wide association studies summary statistics, while for EC, data were sourced from the Endometrial Cancer Association Consortium, the Epidemiology of Endometrial Cancer Consortium, and the UK Biobank. The primary analytical method was inverse-variance weighted. Additional analyses, such as MR-Egger and weighted median, were conducted to validate the robustness of

SUBMITTER: Wu JC 

PROVIDER: S-EPMC11495734 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature