Construction and multiple validations of a robust ferroptosis-related prognostic model in bladder cancer: A comprehensive study.

ABSTRACT: Ferroptosis is iron-dependent programmed cell death that inhibits tumor growth, particularly in traditional treatment-resistant tumors. Prognostic models constructed from ferroptosis-related genes are lacking; prognostic biomarkers remain insufficient. We acquired gene expression data and corresponding clinical information for bladder cancer (BC) samples from public databases. Ferroptosis-related genes from the ferroptosis database were screened for clinical predictive value. We validated gene expression differences between tumors and normal tissues through polymerase chain reaction and western blotting. Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses were conducted to explore signaling pathways affecting the overall survival of patients with BC. CIBERSORT was

SUBMITTER: Dai X 

PROVIDER: S-EPMC11495766 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature