The causal association between immune cells and gout: A bidirectional two-sample Mendelian randomization study.

ABSTRACT: Gout, a metabolic disorder, is increasingly being linked to immune cells. However, the causal relationships between these factors remain unclear. Our study aimed to elucidate the causal relationship between immune cells and gout. Our study used 2-sample Mendelian randomization (MR) to explore the causal relationship between immune cells and gout. It is noteworthy that we utilized 5 methods MR-Egger, weighted median, inverse variance weighted, weighted mode, and simple mode to ensure the reliability of the results. Comprehensive sensitivity analyses were performed to verify the robustness, heterogeneity, and horizontal pleiotropy of the results. After false discovery rate correction (PFDR <0.20), 3 immunophenotypes were identified: one in the B cell panel, one in the regulatory T cells pane

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC11495775 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature